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aggregation process cellular

Entropy measures of cellular aggregation ScienceDirect

01/07/2009· Migration and aggregation of cells require complex interactions, not yet completely understood, among extracellular matrix molecules, released soluble factors, membrane receptors, enzymes, cytoskeleton and endocytic vesicles ,.

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Putting huntingtin "aggregation" in view with windows into

Challenges remain in defining the aggregation process at the molecular level and how this process is influenced by, or influences cellular activities. Insight is further confounded by the term "aggregation" being used to describe a composite of distinct processes that may have opposing consequences to cell health and survival. This review discusses these issues in light of a historic summary

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Cell Aggregation an overview ScienceDirect Topics

Cell aggregation is a typical bioengineering method that aims to reconstitute bioengineered organ germ that will properly reproduce epithelial–mesenchymal interactions and organogenesis (Sharpe and Young, 2005; Yen and Sharpe, 2006).

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Aggregation and Cellular Toxicity of Pathogenic or Non

The aggregation process of HEWL can be accelerated when the protein is at higher temperatures (e.g. 60 °C, 65 °C, and 80 °C) 42. The aggregation kinetics also depends on the protein

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High-content analysis of α-synuclein aggregation and cell

Background: Alpha-synuclein (α-SYN) aggregates represent a key feature of Parkinson's disease, but the exact relationship between α-SYN aggregation and neurodegeneration remains incompletely understood. Therefore, the availability of a cellular assay that allows medium-throughput analysis of α-SYN-linked pathology will be of great value for studying the aggregation process and for advancing

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Chemotaxis and Aggregation in the Cellular Slime Mould

During a phase of its life cycle, many individual amoebae aggregate to form a fruiting body. Aggregation proceeds under the influence of concentra- tion waves of the signalling molecule cAMP to...

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Protein aggregation Wikipedia

Cells have mechanisms that can refold or degrade protein aggregates. However, as cells age, these control mechanisms are weakened and the cell is less able to resolve the aggregates. The hypothesis that protein aggregation is a causative process in aging is testable now since some models of delayed aging are in hand.

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Pathogenic alpha-synuclein aggregates preferentially bind

affect cellular respiration Xinhe Wang1, Katelyn Becker1, Nathan Levine1, Michelle Zhang1, pathogenic process and is commonly used to indicate the pathogenic αSyn species [1, 14]. In addition to PD, αSyn aggregation is also a common pathological hallmark for a group of neurodegenerative diseases known as α-synucleinopathies, which include PD, dementia with Lewy bodies (DLB), and

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Frontiers Cellular Regulation of Amyloid Formation in

The role of these aggregates in disease is not fully understood: the most prevalent hypothesis is that aggregation intermediates—single or complexes of aggregation-prone proteins—are toxic to cells and that the aggregation process represents a cellular protection mechanism against these toxic intermediates (Lansbury and Lashuel, 2006; Hartl and Hayer-Hartl, 2009).

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cellular process Traduction en français exemples

Traductions en contexte de "cellular process" en anglais-français avec Reverso Context : Degranulation is a cellular process that releases antimicrobial cytotoxic or other molecules from secretory vesicles called granules found inside some cells.

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High-content analysis of α-synuclein aggregation and cell

Background: Alpha-synuclein (α-SYN) aggregates represent a key feature of Parkinson's disease, but the exact relationship between α-SYN aggregation and neurodegeneration remains incompletely understood. Therefore, the availability of a cellular assay that allows medium-throughput analysis of α-SYN-linked pathology will be of great value for studying the aggregation process and for advancing

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US2021956A Cellular aggregate and process Google

Cellular aggregate and process Download PDF Info Publication number US2021956A. US2021956A US624660A US62466032A US2021956A US 2021956 A US2021956 A US 2021956A US 624660 A US624660 A US 624660A US 62466032 A US62466032 A US 62466032A US 2021956 A US2021956 A US 2021956A Authority US United States Prior art keywords material pieces process heat cellular

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Frontiers Immunogenicity of Bioproducts: Cellular Models

Aggregation can occur at any stage of the manufacturing process, storage, transportation, or preparation for patient administration, under the influence of several critical environmental parameters (e.g., temperature, pH, ionic strength, shear forces, light, etc.). These stress conditions can alter the protein structure either by physical or by chemical damage and trigger the protein

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Cellular strategies for controlling protein aggregation

The aggregation of misfolded proteins is associated with the perturbation of cellular function, ageing and various human disorders. Mounting evidence suggests that protein aggregation is often part of the cellular response to an imbalanced protein homeostasis rather than an unspecific and uncontrolled dead-end pathway. It is a regulated process in cells from bacteria to humans, leading to the

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Cellular pattern formation during Dictyostelium aggregation

Here we derive a model of the actual cell aggregation process by considering the chemotactic cell response to cAMP and its interplay with the cAMP dynamics. Cell density, which previously has been treated as a spatially homogeneous parameter, is a crucial variable of the aggregation model. We find that the coupled dynamics of cell chemotaxis and cAMP reaction-diffusion lead to the break-up of

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Cellular strategies for controlling protein aggregation

cellular function, ageing and various human disorders. Mounting evidence suggests that Mounting evidence suggests that protein aggregation is often part of the cellular response to an imbalanced

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Genetic Studies of mrp, a Locus Essential for Cellular

Under starvation conditions, Myxococcus xanthus undergoes a complex developmental process which includes cellular aggregation and sporulation. A transposon insertion mutant (the Tn 5 -Ω280 mutant) with defects in both aggregation and sporulation was analyzed in this study. The Tn 5 -Ω280 mutant was found to have a disrupted NtrC-like response regulator designated Myxococcus regulatory

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Cellular aggregation definition of cellular aggregation

Define cellular aggregation. cellular aggregation synonyms, cellular aggregation pronunciation, cellular aggregation translation, English dictionary definition of cellular aggregation. adj. 1. Constituting or amounting to a whole; total: aggregate sales in that market. 2. Botany Crowded or massed into a dense cluster. 3. Composed of a Cellular aggregation definition of cellular

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Frontiers Cellular Regulation of Amyloid Formation in

The role of these aggregates in disease is not fully understood: the most prevalent hypothesis is that aggregation intermediates—single or complexes of aggregation-prone proteins—are toxic to cells and that the aggregation process represents a cellular protection mechanism against these toxic intermediates (Lansbury and Lashuel, 2006; Hartl and Hayer-Hartl, 2009).

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